Thutmosis III co-reigned for 22 years alongside his stepmother Hatshepsut, as she felt that she was more justified to rule and did not allow him to take the reins when he grew older.  She insisted on adding the title 'Egypt's King' next to her name on all her monuments.  On her death, Thutmosis obliterated her name from her monuments and the fate of her daughter Neferura is also unknown.
Thutmosis III conducted a great number of military campaigns on his neighbours to secure Egypt's borders and to expand his realm from south Syria to Nubia. The most famous battle was the Battle of Megiddo, which he depicted in detail on the walls of the Amon Temple at Karnak.  He launched an extensive building programme all over Egypt and Nubia ranging from temples in Karnak and Luxor to tombs for the nobles.
Egypt experienced an economic boom when he annexed Palestine and Nubia, based on the wealth of natural resources such as gold and minerals from Nubia and agricultural produce from Palestine.
Thutmosis III married foreign princesses which he brought to Egypt to cement alliances with his neighbours.  They bore him children.